The effect of weight loss on whole-body and tissue-specific insulin sensitivity and hepatic lipid content and composition: SWEET substudy
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- Pang et al_Obesity_2023_Vol 31(7)_1745-1754
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Objective: This study (1) investigated the effect of weight loss on whole-body and tissue-specific insulin sensitivity and on intrahepatic lipid (IHL) content and composition and (2) investigated the association between weight-loss-induced changes in insulin sensitivity and IHL content in individuals with overweight or obesity.
Methods: In this secondary analysis of the European SWEET project, 50 adults (age 18–65 years) with overweight or obesity (BMI ≥ 25 kg/m2) followed a low-energy diet (LED) for 2 months. At baseline and after the LED, body composition (dual-energy x-ray absorptiometry), IHL content and composition (proton magnetic resonance spectroscopy), whole-body insulin sensitivity (Matsuda index), muscle insulin sensitivity index (MISI), and hepatic insulin resistance index (HIRI) were determined (7-point oral glucose tolerance test).
Results: The LED reduced body weight (p < 0.001). This was accompanied by increased Matsuda index and reduced HIRI (both p < 0.001) but no change in MISI (p = 0.260). Weight loss decreased IHL content (mean [SEM], 3.9% [0.7%] vs. 1.6% [0.5%], p < 0.001) and the hepatic saturated fatty acid fraction (41.0% [1.5%] vs. 36.6% [1.9%], p = 0.039). The reduced IHL content was associated with an improvement in HIRI (r = 0.402, p = 0.025).
Conclusions: Weight loss decreased IHL content and the hepatic saturated fatty acid fraction. The decrease in IHL content was associated with weight-loss-induced improvement in hepatic insulin sensitivity in individuals with overweight or obesity.
Originalsprog | Engelsk |
---|---|
Tidsskrift | Obesity |
Vol/bind | 31 |
Udgave nummer | 7 |
Sider (fra-til) | 1745-1754 |
Antal sider | 10 |
ISSN | 1930-7381 |
DOI | |
Status | Udgivet - 2023 |
Bibliografisk note
CURIS 2023 NEXS 170
Funding Information:
The work was supported by the Horizon 2020 project “SWEET” ( http://www.sweetproject.eu , 2018–2023, Grant Agreement ID 774293) according to Program H2020‐EU.3.2.2.2. Biochemical analyses of the oral glucose tolerance test are funded by the budget of the principal investigator's (EEB) research group ( http://www.nimolab.nl ). VBS‐H was supported by an European Research Council (ERC) starting grant (grant number 759161, “MRS in diabetes”). The study sponsor/funder was not involved in the design of the study, the collection, analysis, and interpretation of data, or writing the report and did not impose any restrictions regarding the publication of the report.
Publisher Copyright:
© 2023 The Authors. Obesity published by Wiley Periodicals LLC on behalf of The Obesity Society.
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