TY - JOUR

T1 - Variation in human water turnover associated with environmental and lifestyle factors

AU - Yamada, Yosuke

AU - Zhang, Xueying

AU - Henderson, Mary E T

AU - Sagayama, Hiroyuki

AU - Pontzer, Herman

AU - Watanabe, Daiki

AU - Yoshida, Tsukasa

AU - Kimura, Misaka

AU - Ainslie, Philip N

AU - Andersen, Lene F

AU - Anderson, Liam J

AU - Arab, Lenore

AU - Baddou, Issad

AU - Bedu-Addo, Kweku

AU - Blaak, Ellen E

AU - Blanc, Stephane

AU - Bonomi, Alberto G

AU - Bouten, Carlijn V C

AU - Bovet, Pascal

AU - Buchowski, Maciej S

AU - Butte, Nancy F

AU - Camps, Stefan G

AU - Close, Graeme L

AU - Cooper, Jamie A

AU - Cooper, Richard

AU - Das, Sai Krupa

AU - Dugas, Lara R

AU - Eaton, Simon

AU - Ekelund, Ulf

AU - Entringer, Sonja

AU - Forrester, Terrence

AU - Fudge, Barry W

AU - Goris, Annelies H

AU - Gurven, Michael

AU - Halsey, Lewis G

AU - Hambly, Catherine

AU - El Hamdouchi, Asmaa

AU - Hoos, Marije B

AU - Hu, Sumei

AU - Joonas, Noorjehan

AU - Joosen, Annemiek M

AU - Katzmarzyk, Peter

AU - Kempen, Kitty P

AU - Kraus, William E

AU - Kriengsinyos, Wantanee

AU - Kushner, Robert F

AU - Lambert, Estelle V

AU - Leonard, William R

AU - Sjödin, Anders M

AU - Wood, Brian M

AU - International Atomic Energy Agency (IAEA) Doubly Labeled Water (DLW) Database Consortium§

N1 - CURIS 2022 NEXS 280

PY - 2022

Y1 - 2022

N2 - Water is essential for survival, but one in three individuals worldwide (2.2 billion people) lacks access to safe drinking water. Water intake requirements largely reflect water turnover (WT), the water used by the body each day. We investigated the determinants of human WT in 5604 people from the ages of 8 days to 96 years from 23 countries using isotope-tracking (2H) methods. Age, body size, and composition were significantly associated with WT, as were physical activity, athletic status, pregnancy, socioeconomic status, and environmental characteristics (latitude, altitude, air temperature, and humidity). People who lived in countries with a low human development index (HDI) had higher WT than people in high-HDI countries. On the basis of this extensive dataset, we provide equations to predict human WT in relation to anthropometric, economic, and environmental factors.

AB - Water is essential for survival, but one in three individuals worldwide (2.2 billion people) lacks access to safe drinking water. Water intake requirements largely reflect water turnover (WT), the water used by the body each day. We investigated the determinants of human WT in 5604 people from the ages of 8 days to 96 years from 23 countries using isotope-tracking (2H) methods. Age, body size, and composition were significantly associated with WT, as were physical activity, athletic status, pregnancy, socioeconomic status, and environmental characteristics (latitude, altitude, air temperature, and humidity). People who lived in countries with a low human development index (HDI) had higher WT than people in high-HDI countries. On the basis of this extensive dataset, we provide equations to predict human WT in relation to anthropometric, economic, and environmental factors.

KW - Faculty of Science

KW - Human water turnover

KW - Lifestyle

KW - Environmental characteristics

KW - Anthropometric factors

KW - Economic factors

KW - Environmental factors

U2 - 10.1126/science.abm8668

DO - 10.1126/science.abm8668

M3 - Journal article

C2 - 36423296

VL - 378

SP - 909

EP - 915

JO - Science

JF - Science

SN - 0036-8075

IS - 6622

ER -