Low diversity of foot-and-mouth disease serotype C virus in Kenya: evidence for probable vaccine strain re-introductions in the field

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Standard

Low diversity of foot-and-mouth disease serotype C virus in Kenya : evidence for probable vaccine strain re-introductions in the field. / Sangula, A K; Siegismund, H R; Belsham, G J; Balinda, S N; Masembe, C; Muwanika, V B.

I: Epidemiology and Infection, Bind 139, Nr. 2, 2011, s. 189-196.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Sangula, AK, Siegismund, HR, Belsham, GJ, Balinda, SN, Masembe, C & Muwanika, VB 2011, 'Low diversity of foot-and-mouth disease serotype C virus in Kenya: evidence for probable vaccine strain re-introductions in the field', Epidemiology and Infection, bind 139, nr. 2, s. 189-196. https://doi.org/10.1017/S0950268810000580

APA

Sangula, A. K., Siegismund, H. R., Belsham, G. J., Balinda, S. N., Masembe, C., & Muwanika, V. B. (2011). Low diversity of foot-and-mouth disease serotype C virus in Kenya: evidence for probable vaccine strain re-introductions in the field. Epidemiology and Infection, 139(2), 189-196. https://doi.org/10.1017/S0950268810000580

Vancouver

Sangula AK, Siegismund HR, Belsham GJ, Balinda SN, Masembe C, Muwanika VB. Low diversity of foot-and-mouth disease serotype C virus in Kenya: evidence for probable vaccine strain re-introductions in the field. Epidemiology and Infection. 2011;139(2):189-196. https://doi.org/10.1017/S0950268810000580

Author

Sangula, A K ; Siegismund, H R ; Belsham, G J ; Balinda, S N ; Masembe, C ; Muwanika, V B. / Low diversity of foot-and-mouth disease serotype C virus in Kenya : evidence for probable vaccine strain re-introductions in the field. I: Epidemiology and Infection. 2011 ; Bind 139, Nr. 2. s. 189-196.

Bibtex

@article{4cdefa40a47311df928f000ea68e967b,
title = "Low diversity of foot-and-mouth disease serotype C virus in Kenya: evidence for probable vaccine strain re-introductions in the field",
abstract = "Most viruses are maintained by complex processes of evolution that enable them to survive but also complicate efforts to achieve their control. In this paper, we study patterns of evolution in foot-and-mouth disease (FMD) serotype C virus isolates from Kenya, one of the few places in the world where serotype C has been endemic and is suspected to remain. The nucleotide sequences encoding the capsid protein VP1 from eight isolates collected between 1967 and 2004 were analysed for patterns of sequence divergence and evolution. Very low nucleotide diversity (pi=0.0025) and remarkably little change (only five segregating sites and three amino-acid changes) were observed in these isolates collected over a period of almost 40 years. We interpret these results as being suggestive of re-introductions of the vaccine strain into the field. The implications of these results for the maintenance of serotype C FMD virus and the use of vaccination as a control measure in Kenya are discussed.",
keywords = "Faculty of Science, FMDV serotype C, Kenya, sequence divergence, vaccine strain",
author = "Sangula, {A K} and Siegismund, {H R} and Belsham, {G J} and Balinda, {S N} and C Masembe and Muwanika, {V B}",
year = "2011",
doi = "10.1017/S0950268810000580",
language = "English",
volume = "139",
pages = "189--196",
journal = "Epidemiology and Infection",
issn = "0950-2688",
publisher = "Cambridge University Press",
number = "2",

}

RIS

TY - JOUR

T1 - Low diversity of foot-and-mouth disease serotype C virus in Kenya

T2 - evidence for probable vaccine strain re-introductions in the field

AU - Sangula, A K

AU - Siegismund, H R

AU - Belsham, G J

AU - Balinda, S N

AU - Masembe, C

AU - Muwanika, V B

PY - 2011

Y1 - 2011

N2 - Most viruses are maintained by complex processes of evolution that enable them to survive but also complicate efforts to achieve their control. In this paper, we study patterns of evolution in foot-and-mouth disease (FMD) serotype C virus isolates from Kenya, one of the few places in the world where serotype C has been endemic and is suspected to remain. The nucleotide sequences encoding the capsid protein VP1 from eight isolates collected between 1967 and 2004 were analysed for patterns of sequence divergence and evolution. Very low nucleotide diversity (pi=0.0025) and remarkably little change (only five segregating sites and three amino-acid changes) were observed in these isolates collected over a period of almost 40 years. We interpret these results as being suggestive of re-introductions of the vaccine strain into the field. The implications of these results for the maintenance of serotype C FMD virus and the use of vaccination as a control measure in Kenya are discussed.

AB - Most viruses are maintained by complex processes of evolution that enable them to survive but also complicate efforts to achieve their control. In this paper, we study patterns of evolution in foot-and-mouth disease (FMD) serotype C virus isolates from Kenya, one of the few places in the world where serotype C has been endemic and is suspected to remain. The nucleotide sequences encoding the capsid protein VP1 from eight isolates collected between 1967 and 2004 were analysed for patterns of sequence divergence and evolution. Very low nucleotide diversity (pi=0.0025) and remarkably little change (only five segregating sites and three amino-acid changes) were observed in these isolates collected over a period of almost 40 years. We interpret these results as being suggestive of re-introductions of the vaccine strain into the field. The implications of these results for the maintenance of serotype C FMD virus and the use of vaccination as a control measure in Kenya are discussed.

KW - Faculty of Science

KW - FMDV serotype C

KW - Kenya

KW - sequence divergence

KW - vaccine strain

U2 - 10.1017/S0950268810000580

DO - 10.1017/S0950268810000580

M3 - Journal article

C2 - 20334728

VL - 139

SP - 189

EP - 196

JO - Epidemiology and Infection

JF - Epidemiology and Infection

SN - 0950-2688

IS - 2

ER -

ID: 21307749