GDF15 increases insulin action in the liver and adipose tissue via a β-adrenergic receptor-mediated mechanism

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Standard

GDF15 increases insulin action in the liver and adipose tissue via a β-adrenergic receptor-mediated mechanism. / Sjøberg, Kim Anker; Sigvardsen, Casper Møller; Alvarado-Diaz, Abdiel; Andersen, Nicoline Resen; Larance, Mark; Seeley, Randy J; Schjerling, Peter; Knudsen, Jakob Grunnet; Katzilieris-Petras, Georgios; Clemmensen, Christoffer; Jørgensen, Sebastian Beck; De Bock, Katrien; Richter, Erik A.

I: Cell Metabolism, Bind 35, Nr. 8, 2023, s. 1327-1340.e5.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Sjøberg, KA, Sigvardsen, CM, Alvarado-Diaz, A, Andersen, NR, Larance, M, Seeley, RJ, Schjerling, P, Knudsen, JG, Katzilieris-Petras, G, Clemmensen, C, Jørgensen, SB, De Bock, K & Richter, EA 2023, 'GDF15 increases insulin action in the liver and adipose tissue via a β-adrenergic receptor-mediated mechanism', Cell Metabolism, bind 35, nr. 8, s. 1327-1340.e5. https://doi.org/10.1016/j.cmet.2023.06.016

APA

Sjøberg, K. A., Sigvardsen, C. M., Alvarado-Diaz, A., Andersen, N. R., Larance, M., Seeley, R. J., Schjerling, P., Knudsen, J. G., Katzilieris-Petras, G., Clemmensen, C., Jørgensen, S. B., De Bock, K., & Richter, E. A. (2023). GDF15 increases insulin action in the liver and adipose tissue via a β-adrenergic receptor-mediated mechanism. Cell Metabolism, 35(8), 1327-1340.e5. https://doi.org/10.1016/j.cmet.2023.06.016

Vancouver

Sjøberg KA, Sigvardsen CM, Alvarado-Diaz A, Andersen NR, Larance M, Seeley RJ o.a. GDF15 increases insulin action in the liver and adipose tissue via a β-adrenergic receptor-mediated mechanism. Cell Metabolism. 2023;35(8):1327-1340.e5. https://doi.org/10.1016/j.cmet.2023.06.016

Author

Sjøberg, Kim Anker ; Sigvardsen, Casper Møller ; Alvarado-Diaz, Abdiel ; Andersen, Nicoline Resen ; Larance, Mark ; Seeley, Randy J ; Schjerling, Peter ; Knudsen, Jakob Grunnet ; Katzilieris-Petras, Georgios ; Clemmensen, Christoffer ; Jørgensen, Sebastian Beck ; De Bock, Katrien ; Richter, Erik A. / GDF15 increases insulin action in the liver and adipose tissue via a β-adrenergic receptor-mediated mechanism. I: Cell Metabolism. 2023 ; Bind 35, Nr. 8. s. 1327-1340.e5.

Bibtex

@article{2174750a3b2f4eee87698bf70187301a,

title = "GDF15 increases insulin action in the liver and adipose tissue via a β-adrenergic receptor-mediated mechanism",

abstract = "Growth differentiation factor 15 (GDF15) induces weight loss and increases insulin action in obese rodents. Whether and how GDF15 improves insulin action without weight loss is unknown. Obese rats were treated with GDF15 and displayed increased insulin tolerance 5 h later. Lean and obese female and male mice were treated with GDF15 on days 1, 3, and 5 without weight loss and displayed increased insulin sensitivity during a euglycemic hyperinsulinemic clamp on day 6 due to enhanced suppression of endogenous glucose production and increased glucose uptake in WAT and BAT. GDF15 also reduced glucagon levels during clamp independently of the GFRAL receptor. The insulin-sensitizing effect of GDF15 was completely abrogated in GFRAL KO mice and also by treatment with the β-adrenergic antagonist propranolol and in β1,β2-adrenergic receptor KO mice. GDF15 activation of the GFRAL receptor increases β-adrenergic signaling, in turn, improving insulin action in the liver and white and brown adipose tissue.",

keywords = "Faculty of Science, Insulin sensitivity, Euglycemic clamp, Appetite control, Insulin resistance, Glucose metabolism, GFRAL receptor, Adrenergic receptors, Glucagon",

author = "Sj{\o}berg, {Kim Anker} and Sigvardsen, {Casper M{\o}ller} and Abdiel Alvarado-Diaz and Andersen, {Nicoline Resen} and Mark Larance and Seeley, {Randy J} and Peter Schjerling and Knudsen, {Jakob Grunnet} and Georgios Katzilieris-Petras and Christoffer Clemmensen and J{\o}rgensen, {Sebastian Beck} and {De Bock}, Katrien and Richter, {Erik A.}",

year = "2023",

doi = "10.1016/j.cmet.2023.06.016",

language = "English",

volume = "35",

pages = "1327--1340.e5",

journal = "Cell Metabolism",

issn = "1550-4131",

publisher = "Cell Press",

number = "8",

}

RIS

TY - JOUR

T1 - GDF15 increases insulin action in the liver and adipose tissue via a β-adrenergic receptor-mediated mechanism

AU - Sjøberg, Kim Anker

AU - Sigvardsen, Casper Møller

AU - Alvarado-Diaz, Abdiel

AU - Andersen, Nicoline Resen

AU - Larance, Mark

AU - Seeley, Randy J

AU - Schjerling, Peter

AU - Knudsen, Jakob Grunnet

AU - Katzilieris-Petras, Georgios

AU - Clemmensen, Christoffer

AU - Jørgensen, Sebastian Beck

AU - De Bock, Katrien

AU - Richter, Erik A.

PY - 2023

Y1 - 2023

N2 - Growth differentiation factor 15 (GDF15) induces weight loss and increases insulin action in obese rodents. Whether and how GDF15 improves insulin action without weight loss is unknown. Obese rats were treated with GDF15 and displayed increased insulin tolerance 5 h later. Lean and obese female and male mice were treated with GDF15 on days 1, 3, and 5 without weight loss and displayed increased insulin sensitivity during a euglycemic hyperinsulinemic clamp on day 6 due to enhanced suppression of endogenous glucose production and increased glucose uptake in WAT and BAT. GDF15 also reduced glucagon levels during clamp independently of the GFRAL receptor. The insulin-sensitizing effect of GDF15 was completely abrogated in GFRAL KO mice and also by treatment with the β-adrenergic antagonist propranolol and in β1,β2-adrenergic receptor KO mice. GDF15 activation of the GFRAL receptor increases β-adrenergic signaling, in turn, improving insulin action in the liver and white and brown adipose tissue.

AB - Growth differentiation factor 15 (GDF15) induces weight loss and increases insulin action in obese rodents. Whether and how GDF15 improves insulin action without weight loss is unknown. Obese rats were treated with GDF15 and displayed increased insulin tolerance 5 h later. Lean and obese female and male mice were treated with GDF15 on days 1, 3, and 5 without weight loss and displayed increased insulin sensitivity during a euglycemic hyperinsulinemic clamp on day 6 due to enhanced suppression of endogenous glucose production and increased glucose uptake in WAT and BAT. GDF15 also reduced glucagon levels during clamp independently of the GFRAL receptor. The insulin-sensitizing effect of GDF15 was completely abrogated in GFRAL KO mice and also by treatment with the β-adrenergic antagonist propranolol and in β1,β2-adrenergic receptor KO mice. GDF15 activation of the GFRAL receptor increases β-adrenergic signaling, in turn, improving insulin action in the liver and white and brown adipose tissue.

KW - Faculty of Science

KW - Insulin sensitivity

KW - Euglycemic clamp

KW - Appetite control

KW - Insulin resistance

KW - Glucose metabolism

KW - GFRAL receptor

KW - Adrenergic receptors

KW - Glucagon

U2 - 10.1016/j.cmet.2023.06.016

DO - 10.1016/j.cmet.2023.06.016

M3 - Journal article

C2 - 37473755

VL - 35

SP - 1327-1340.e5

JO - Cell Metabolism

JF - Cell Metabolism

SN - 1550-4131

IS - 8

ER -

ID: 360706013

Saxo-Instituttet