TY - JOUR

T1 - Effect of high doses of L-ascorbic acid on the antioxidative/oxidative state in the rats

AU - Niemiec, T.

AU - Sawosz, E.

AU - Chwalibog, André

PY - 2005

Y1 - 2005

N2 - The objective of this study was to determine the effects of mega-doses of vitamin C (0.3, 0.6 and 0.9% of diet) as a dietary supplement for rats on selected indices of the antioxidative/oxidative state in 40 growing Wistar rats (4x10). It was found that L-ascorbic acid and Total Antioxidative State (TAS) in plasma did not increase with increasing vitamin C supply. The results indicate that high doses of L-ascorbic acid (0.3 and 0.9 but not 0.6%) increased the concentration of this antioxidant in plasma. Supplementation of vitamin C above 0.3% to the diets had pro-oxidative effects on lipid structures, while application of 0.9% promoted oxidative degradation of rat livers.

AB - The objective of this study was to determine the effects of mega-doses of vitamin C (0.3, 0.6 and 0.9% of diet) as a dietary supplement for rats on selected indices of the antioxidative/oxidative state in 40 growing Wistar rats (4x10). It was found that L-ascorbic acid and Total Antioxidative State (TAS) in plasma did not increase with increasing vitamin C supply. The results indicate that high doses of L-ascorbic acid (0.3 and 0.9 but not 0.6%) increased the concentration of this antioxidant in plasma. Supplementation of vitamin C above 0.3% to the diets had pro-oxidative effects on lipid structures, while application of 0.9% promoted oxidative degradation of rat livers.

KW - Former LIFE faculty

KW - ascorbic acid

KW - antioxidative/oxidative state

KW - rats

M3 - Journal article

VL - 14

SP - 553

EP - 556

JO - Journal of Animal and Feed Sciences

JF - Journal of Animal and Feed Sciences

SN - 1230-1388

IS - Suppl.1

ER -