The aims of this study were (i) to characterise the acceleration demands of two different formats of small-sided game (SSG), i.e., 4v4 + goalkeepers (4v4 + GK) and 8v8 + goalkeepers (8v8 + GK); (ii) to analyse the correlation between performance in power-based tests and acceleration-based physical loading during the two different SSG formats and (iii) to analyse the neuromuscular-induced fatigue. Eighteen adult male footballers participated in the study (20.7 ± 1.0 years, 178 ± 5 cm and 71.4 ± 2.1 kg). Baseline measurements were obtained from countermovement jumps, 15 s repeated jumps and 5 and 15 m sprints. A total of 36 min was analysed for each SSG (4v4 + GK: two sets of 3 × 6 min, and 8v8 + GK: 2 × 18 min). Heart rate, blood lactate, perceived exertion and movement pattern (GPS) were analysed. Distances covered by very-high-intensity activities and very-high-speed running were lower in 4v4 + GK than in 8v8 + GK (effect sizes (ES) = -0.69 ± 0.67 and -1.04 ± 0.67, respectively; very likely), while accelerations and decelerations were higher in 4v4 + GK than in 8v8 + GK (ES = 1.13-1.52; almost certainly). Blood lactate concentrations were higher (ES = 1.40 ± 0.58; almost certainly) and players perceived themselves to be more tired (ES = 0.80-2.31; almost certainly) after 4v4 + GK than after 8v8 + GK. Sprint ability in 5 and 15 m tests decreased (ES = 0.87 ± 0.58 and 0.89 ± 0.58, respectively; almost certainly) only after 4v4 + GK. This SSG format appeared more demanding in relation to repetitions and fatigue development of muscle power-based actions than 8v8 + GK. It may therefore be logical to use the former type of SSG to target development of power-related football actions.