Counteracting age-related loss of skeletal muscle mass: a clinical and ethnological trial on the role of protein supplementation and training load (CALM Intervention Study): study protocol for a randomized controlled trial
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Counteracting age-related loss of skeletal muscle mass : a clinical and ethnological trial on the role of protein supplementation and training load (CALM Intervention Study): study protocol for a randomized controlled trial. / Bechshøft, Rasmus; Reitelseder, Søren; Højfeldt, Grith Stougaard; Castro Mejia, Josue Leonardo; Khakimov, Bekzod; Bin Ahmad, Hajar Fauzan; Kjær, Michael; Engelsen, Søren Balling; Laugesen, Susanne Margrete Bølling; Rasmussen, Morten Arendt; Lassen, Aske Juul; Jensen, Tenna; Beyer, Nina; Serena, Anja; Perez-Cueto, Armando; Nielsen, Dennis Sandris; Jespersen, Astrid Pernille; Holm, Lars.
I: Trials, Bind 17, 397, 2016.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Counteracting age-related loss of skeletal muscle mass
T2 - a clinical and ethnological trial on the role of protein supplementation and training load (CALM Intervention Study): study protocol for a randomized controlled trial
AU - Bechshøft, Rasmus
AU - Reitelseder, Søren
AU - Højfeldt, Grith Stougaard
AU - Castro Mejia, Josue Leonardo
AU - Khakimov, Bekzod
AU - Bin Ahmad, Hajar Fauzan
AU - Kjær, Michael
AU - Engelsen, Søren Balling
AU - Laugesen, Susanne Margrete Bølling
AU - Rasmussen, Morten Arendt
AU - Lassen, Aske Juul
AU - Jensen, Tenna
AU - Beyer, Nina
AU - Serena, Anja
AU - Perez-Cueto, Armando
AU - Nielsen, Dennis Sandris
AU - Jespersen, Astrid Pernille
AU - Holm, Lars
PY - 2016
Y1 - 2016
N2 - BackgroundAging is associated with decreased muscle mass and functional capacity, which in turn decrease quality of life. The number of citizens over the age of 65 years in the Western world will increase by 50 % over the next four decades, and this demographic shift brings forth new challenges at both societal and individual levels. Only a few longitudinal studies have been reported, but whey protein supplementation seems to improve muscle mass and function, and its combination with heavy strength training appears even more effective. However, heavy resistance training may reduce adherence to training, thereby attenuating the overall benefits of training. We hypothesize that light load resistance training is more efficient when both adherence and physical improvement are considered longitudinally. We launched the interdisciplinary project on Counteracting Age-related Loss of Skeletal Muscle Mass (CALM) to investigate the impact of lifestyle changes on physical and functional outcomes as well as everyday practices and habits in a qualitative context.MethodsWe will randomize 205 participants older than 65 years to be given 1 year of two daily nutrient supplements with 10 g of sucrose and 20 g of either collagen protein, carbohydrates, or whey. Further, two groups will perform either heavy progressive resistance training or light load training on top of the whey supplement.DiscussionThe primary outcome of the CALM Intervention Study is the change in thigh cross-sectional area. Moreover, we will evaluate changes in physical performance, muscle fiber type and acute anabolic response to whey protein ingestion, sensory adaptation, gut microbiome, and a range of other measures, combined with questionnaires on life quality and qualitative interviews with selected subjects. The CALM Intervention Study will generate scientific evidence and recommendations to counteract age-related loss of skeletal muscle mass in elderly individuals.
AB - BackgroundAging is associated with decreased muscle mass and functional capacity, which in turn decrease quality of life. The number of citizens over the age of 65 years in the Western world will increase by 50 % over the next four decades, and this demographic shift brings forth new challenges at both societal and individual levels. Only a few longitudinal studies have been reported, but whey protein supplementation seems to improve muscle mass and function, and its combination with heavy strength training appears even more effective. However, heavy resistance training may reduce adherence to training, thereby attenuating the overall benefits of training. We hypothesize that light load resistance training is more efficient when both adherence and physical improvement are considered longitudinally. We launched the interdisciplinary project on Counteracting Age-related Loss of Skeletal Muscle Mass (CALM) to investigate the impact of lifestyle changes on physical and functional outcomes as well as everyday practices and habits in a qualitative context.MethodsWe will randomize 205 participants older than 65 years to be given 1 year of two daily nutrient supplements with 10 g of sucrose and 20 g of either collagen protein, carbohydrates, or whey. Further, two groups will perform either heavy progressive resistance training or light load training on top of the whey supplement.DiscussionThe primary outcome of the CALM Intervention Study is the change in thigh cross-sectional area. Moreover, we will evaluate changes in physical performance, muscle fiber type and acute anabolic response to whey protein ingestion, sensory adaptation, gut microbiome, and a range of other measures, combined with questionnaires on life quality and qualitative interviews with selected subjects. The CALM Intervention Study will generate scientific evidence and recommendations to counteract age-related loss of skeletal muscle mass in elderly individuals.
U2 - 10.1186/s13063-016-1512-0
DO - 10.1186/s13063-016-1512-0
M3 - Journal article
C2 - 27507236
VL - 17
JO - Trials
JF - Trials
SN - 1745-6215
M1 - 397
ER -
ID: 166431162