The L-alpha-amino acid receptor GPRC6A is expressed in the islets of Langerhans but is not involved in L-arginine-induced insulin release
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The L-alpha-amino acid receptor GPRC6A is expressed in the islets of Langerhans but is not involved in L-arginine-induced insulin release. / Smajilovic, Sanela; Clemmensen, Christoffer; Johansen, Lars Dan; Wellendorph, Petrine; Holst, Jens Juul; Thams, Peter Grevsen; Ogo, Egbuna; Bräuner-Osborne, Hans.
I: Amino Acids, Bind 44, Nr. 2, 2013, s. 383-390.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - The L-alpha-amino acid receptor GPRC6A is expressed in the islets of Langerhans but is not involved in L-arginine-induced insulin release
AU - Smajilovic, Sanela
AU - Clemmensen, Christoffer
AU - Johansen, Lars Dan
AU - Wellendorph, Petrine
AU - Holst, Jens Juul
AU - Thams, Peter Grevsen
AU - Ogo, Egbuna
AU - Bräuner-Osborne, Hans
N1 - Keywords: GPRC6A, L-Arginine, Insulin release
PY - 2013
Y1 - 2013
N2 - GPRC6A is a seven-transmembrane receptor activated by a wide range of L: -a-amino acids, most potently by L: -arginine and other basic amino acids. The receptor is broadly expressed, but its exact physiological role remains to be elucidated. It is well established that L: -arginine stimulates insulin secretion; therefore, the receptor has been hypothesized to have a role in regulating glucose metabolism. In this study, we demonstrate that GPRC6A is expressed in islets of Langerhans, but activation of the receptor by L-arginine did not stimulate insulin secretion. We also investigated central metabolic parameters in GPRC6A knockout mice compared with wildtype littermates and found no difference in glucose metabolism or body fat percentage when mice were administered a standard chow diet. In conclusion, our data do not support a role for GPRC6A in L-arginine-induced insulin release and glucose metabolism under normal physiological conditions.
AB - GPRC6A is a seven-transmembrane receptor activated by a wide range of L: -a-amino acids, most potently by L: -arginine and other basic amino acids. The receptor is broadly expressed, but its exact physiological role remains to be elucidated. It is well established that L: -arginine stimulates insulin secretion; therefore, the receptor has been hypothesized to have a role in regulating glucose metabolism. In this study, we demonstrate that GPRC6A is expressed in islets of Langerhans, but activation of the receptor by L-arginine did not stimulate insulin secretion. We also investigated central metabolic parameters in GPRC6A knockout mice compared with wildtype littermates and found no difference in glucose metabolism or body fat percentage when mice were administered a standard chow diet. In conclusion, our data do not support a role for GPRC6A in L-arginine-induced insulin release and glucose metabolism under normal physiological conditions.
KW - Faculty of Health and Medical Sciences
U2 - 10.1007/s00726-012-1341-8
DO - 10.1007/s00726-012-1341-8
M3 - Journal article
C2 - 22714012
VL - 44
SP - 383
EP - 390
JO - Amino Acids
JF - Amino Acids
SN - 0939-4451
IS - 2
ER -
ID: 38321500