Neuroprotective and neurological properties of Melissa officinalis

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Standard

Neuroprotective and neurological properties of Melissa officinalis. / López, Víctor; Martín, Sara; Gómez-Serranillos, Maria Pilar; Carretero, Maria Emilia; Jäger, Anna Katharina; Calvo, Maria Isabel.

I: Neurochemical Research, Bind 34, Nr. 11, 2009, s. 1955-1961.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

López, V, Martín, S, Gómez-Serranillos, MP, Carretero, ME, Jäger, AK & Calvo, MI 2009, 'Neuroprotective and neurological properties of Melissa officinalis', Neurochemical Research, bind 34, nr. 11, s. 1955-1961. https://doi.org/10.1007/s11064-009-9981-0

APA

López, V., Martín, S., Gómez-Serranillos, M. P., Carretero, M. E., Jäger, A. K., & Calvo, M. I. (2009). Neuroprotective and neurological properties of Melissa officinalis. Neurochemical Research, 34(11), 1955-1961. https://doi.org/10.1007/s11064-009-9981-0

Vancouver

López V, Martín S, Gómez-Serranillos MP, Carretero ME, Jäger AK, Calvo MI. Neuroprotective and neurological properties of Melissa officinalis. Neurochemical Research. 2009;34(11):1955-1961. https://doi.org/10.1007/s11064-009-9981-0

Author

López, Víctor ; Martín, Sara ; Gómez-Serranillos, Maria Pilar ; Carretero, Maria Emilia ; Jäger, Anna Katharina ; Calvo, Maria Isabel. / Neuroprotective and neurological properties of Melissa officinalis. I: Neurochemical Research. 2009 ; Bind 34, Nr. 11. s. 1955-1961.

Bibtex

@article{c9d0e970ae7211debc73000ea68e967b,
title = "Neuroprotective and neurological properties of Melissa officinalis",
abstract = "Melissa officinalis has traditionally been used due to its effects on nervous system. Both methanolic and aqueous extracts were tested for protective effects on the PC12 cell line, free radical scavenging properties and neurological activities (inhibition of MAO-A and acetylcholinesterase enzymes and affinity to the GABA(A)-benzodiazepine receptor). The results suggest that the plant has a significant (P < 0.05) protective effect on hydrogen peroxide induced toxicity in PC12 cells. The radical scavenging properties were also investigated in cells and in cell free systems, where this plant was shown to be a good free radical scavenger. The MAO-A bioassay was also performed to detect possible antidepressant activities demonstrating that both extracts inhibited this enzyme, which has a key role in neurotransmitters metabolism. However, no activity was detected in the acetylcholinesterase and GABA assays. In general, the methanolic extract was more effective than the aqueous.",
keywords = "Former Faculty of Pharmaceutical Sciences",
author = "V{\'i}ctor L{\'o}pez and Sara Mart{\'i}n and G{\'o}mez-Serranillos, {Maria Pilar} and Carretero, {Maria Emilia} and J{\"a}ger, {Anna Katharina} and Calvo, {Maria Isabel}",
note = "Keywords: Melissa officinalis; Traditional medicine; Neuroprotective; PC12; Antioxidant; MAO",
year = "2009",
doi = "10.1007/s11064-009-9981-0",
language = "English",
volume = "34",
pages = "1955--1961",
journal = "Neurochemical Research",
issn = "0364-3190",
publisher = "Springer",
number = "11",

}

RIS

TY - JOUR

T1 - Neuroprotective and neurological properties of Melissa officinalis

AU - López, Víctor

AU - Martín, Sara

AU - Gómez-Serranillos, Maria Pilar

AU - Carretero, Maria Emilia

AU - Jäger, Anna Katharina

AU - Calvo, Maria Isabel

N1 - Keywords: Melissa officinalis; Traditional medicine; Neuroprotective; PC12; Antioxidant; MAO

PY - 2009

Y1 - 2009

N2 - Melissa officinalis has traditionally been used due to its effects on nervous system. Both methanolic and aqueous extracts were tested for protective effects on the PC12 cell line, free radical scavenging properties and neurological activities (inhibition of MAO-A and acetylcholinesterase enzymes and affinity to the GABA(A)-benzodiazepine receptor). The results suggest that the plant has a significant (P < 0.05) protective effect on hydrogen peroxide induced toxicity in PC12 cells. The radical scavenging properties were also investigated in cells and in cell free systems, where this plant was shown to be a good free radical scavenger. The MAO-A bioassay was also performed to detect possible antidepressant activities demonstrating that both extracts inhibited this enzyme, which has a key role in neurotransmitters metabolism. However, no activity was detected in the acetylcholinesterase and GABA assays. In general, the methanolic extract was more effective than the aqueous.

AB - Melissa officinalis has traditionally been used due to its effects on nervous system. Both methanolic and aqueous extracts were tested for protective effects on the PC12 cell line, free radical scavenging properties and neurological activities (inhibition of MAO-A and acetylcholinesterase enzymes and affinity to the GABA(A)-benzodiazepine receptor). The results suggest that the plant has a significant (P < 0.05) protective effect on hydrogen peroxide induced toxicity in PC12 cells. The radical scavenging properties were also investigated in cells and in cell free systems, where this plant was shown to be a good free radical scavenger. The MAO-A bioassay was also performed to detect possible antidepressant activities demonstrating that both extracts inhibited this enzyme, which has a key role in neurotransmitters metabolism. However, no activity was detected in the acetylcholinesterase and GABA assays. In general, the methanolic extract was more effective than the aqueous.

KW - Former Faculty of Pharmaceutical Sciences

U2 - 10.1007/s11064-009-9981-0

DO - 10.1007/s11064-009-9981-0

M3 - Journal article

C2 - 19760174

VL - 34

SP - 1955

EP - 1961

JO - Neurochemical Research

JF - Neurochemical Research

SN - 0364-3190

IS - 11

ER -

ID: 14856544