TY - JOUR

T1 - Selective loss of blood group antigens during wound healing

AU - Dabelsteen, Erik

AU - Mackenzie, Ian

PY - 1976

Y1 - 1976

N2 - Frozen sections of healing wounds of the oral mucosa of 3 rhesus monkeys were examined by a double layer immunofluorescent technic for the presence of blood group B-like antigens. Antigen activity was present in normal epithelium and in the epithelial outgrowth into the wounds but was absent from the outgrowth following treatment with lipid solvents. This finding suggests that glycoprotein but not glycolipid associated antigen is lost from the surface of epithelial cells during wound healing, a pattern of selective loss which may reflect a difference between regenerative and neoplastic lesions.

AB - Frozen sections of healing wounds of the oral mucosa of 3 rhesus monkeys were examined by a double layer immunofluorescent technic for the presence of blood group B-like antigens. Antigen activity was present in normal epithelium and in the epithelial outgrowth into the wounds but was absent from the outgrowth following treatment with lipid solvents. This finding suggests that glycoprotein but not glycolipid associated antigen is lost from the surface of epithelial cells during wound healing, a pattern of selective loss which may reflect a difference between regenerative and neoplastic lesions.

KW - Faculty of Health and Medical Sciences

KW - mundhule cancer

U2 - 10.1111/j.1699-0463.1976.tb00141.x

DO - 10.1111/j.1699-0463.1976.tb00141.x

M3 - Journal article

VL - 84A

SP - 445

EP - 450

JO - Acta Pathologica et Microbiologica Scandinavica - Section A Pathology

JF - Acta Pathologica et Microbiologica Scandinavica - Section A Pathology

SN - 0365-4184

IS - 6

ER -