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Counteracting age-related loss of skeletal muscle mass: a clinical and ethnological trial on the role of protein supplementation and training load (CALM Intervention Study): study protocol for a randomized controlled trial

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Standard

Counteracting age-related loss of skeletal muscle mass : a clinical and ethnological trial on the role of protein supplementation and training load (CALM Intervention Study): study protocol for a randomized controlled trial. / Bechshøft, Rasmus; Reitelseder, Søren; Højfeldt, Grith; Castro Mejia, Josue Leonardo; Khakimov, Bekzod; Bin Ahmad, Hajar Fauzan; Kjær, Michael; Engelsen, Søren Balling; Laugesen, Susanne Margrete Bølling; Rasmussen, Morten Arendt; Lassen, Aske Juul; Jensen, Tenna; Beyer, Nina; Serena, Anja; Perez-Cueto, Armando; Nielsen, Dennis Sandris; Jespersen, Astrid Pernille; Holm, Lars.

I: Trials, Bind 17, 397, 2016.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Bechshøft, R, Reitelseder, S, Højfeldt, G, Castro Mejia, JL, Khakimov, B, Bin Ahmad, HF, Kjær, M, Engelsen, SB, Laugesen, SMB, Rasmussen, MA, Lassen, AJ, Jensen, T, Beyer, N, Serena, A, Perez-Cueto, A, Nielsen, DS, Jespersen, AP & Holm, L 2016, 'Counteracting age-related loss of skeletal muscle mass: a clinical and ethnological trial on the role of protein supplementation and training load (CALM Intervention Study): study protocol for a randomized controlled trial' Trials, bind 17, 397. https://doi.org/10.1186/s13063-016-1512-0

APA

Bechshøft, R., Reitelseder, S., Højfeldt, G., Castro Mejia, J. L., Khakimov, B., Bin Ahmad, H. F., ... Holm, L. (2016). Counteracting age-related loss of skeletal muscle mass: a clinical and ethnological trial on the role of protein supplementation and training load (CALM Intervention Study): study protocol for a randomized controlled trial. Trials, 17, [397]. https://doi.org/10.1186/s13063-016-1512-0

Vancouver

Bechshøft R, Reitelseder S, Højfeldt G, Castro Mejia JL, Khakimov B, Bin Ahmad HF o.a. Counteracting age-related loss of skeletal muscle mass: a clinical and ethnological trial on the role of protein supplementation and training load (CALM Intervention Study): study protocol for a randomized controlled trial. Trials. 2016;17. 397. https://doi.org/10.1186/s13063-016-1512-0

Author

Bechshøft, Rasmus ; Reitelseder, Søren ; Højfeldt, Grith ; Castro Mejia, Josue Leonardo ; Khakimov, Bekzod ; Bin Ahmad, Hajar Fauzan ; Kjær, Michael ; Engelsen, Søren Balling ; Laugesen, Susanne Margrete Bølling ; Rasmussen, Morten Arendt ; Lassen, Aske Juul ; Jensen, Tenna ; Beyer, Nina ; Serena, Anja ; Perez-Cueto, Armando ; Nielsen, Dennis Sandris ; Jespersen, Astrid Pernille ; Holm, Lars. / Counteracting age-related loss of skeletal muscle mass : a clinical and ethnological trial on the role of protein supplementation and training load (CALM Intervention Study): study protocol for a randomized controlled trial. I: Trials. 2016 ; Bind 17.

Bibtex

@article{ca63113097bf453a8eb23dc462b84408,
title = "Counteracting age-related loss of skeletal muscle mass: a clinical and ethnological trial on the role of protein supplementation and training load (CALM Intervention Study): study protocol for a randomized controlled trial",
abstract = "BackgroundAging is associated with decreased muscle mass and functional capacity, which in turn decrease quality of life. The number of citizens over the age of 65 years in the Western world will increase by 50 {\%} over the next four decades, and this demographic shift brings forth new challenges at both societal and individual levels. Only a few longitudinal studies have been reported, but whey protein supplementation seems to improve muscle mass and function, and its combination with heavy strength training appears even more effective. However, heavy resistance training may reduce adherence to training, thereby attenuating the overall benefits of training. We hypothesize that light load resistance training is more efficient when both adherence and physical improvement are considered longitudinally. We launched the interdisciplinary project on Counteracting Age-related Loss of Skeletal Muscle Mass (CALM) to investigate the impact of lifestyle changes on physical and functional outcomes as well as everyday practices and habits in a qualitative context.MethodsWe will randomize 205 participants older than 65 years to be given 1 year of two daily nutrient supplements with 10 g of sucrose and 20 g of either collagen protein, carbohydrates, or whey. Further, two groups will perform either heavy progressive resistance training or light load training on top of the whey supplement.DiscussionThe primary outcome of the CALM Intervention Study is the change in thigh cross-sectional area. Moreover, we will evaluate changes in physical performance, muscle fiber type and acute anabolic response to whey protein ingestion, sensory adaptation, gut microbiome, and a range of other measures, combined with questionnaires on life quality and qualitative interviews with selected subjects. The CALM Intervention Study will generate scientific evidence and recommendations to counteract age-related loss of skeletal muscle mass in elderly individuals.",
author = "Rasmus Bechsh{\o}ft and S{\o}ren Reitelseder and Grith H{\o}jfeldt and {Castro Mejia}, {Josue Leonardo} and Bekzod Khakimov and {Bin Ahmad}, {Hajar Fauzan} and Michael Kj{\ae}r and Engelsen, {S{\o}ren Balling} and Laugesen, {Susanne Margrete B{\o}lling} and Rasmussen, {Morten Arendt} and Lassen, {Aske Juul} and Tenna Jensen and Nina Beyer and Anja Serena and Armando Perez-Cueto and Nielsen, {Dennis Sandris} and Jespersen, {Astrid Pernille} and Lars Holm",
year = "2016",
doi = "10.1186/s13063-016-1512-0",
language = "English",
volume = "17",
journal = "Trials",
issn = "1745-6215",
publisher = "BioMed Central Ltd.",

}

RIS

TY - JOUR

T1 - Counteracting age-related loss of skeletal muscle mass

T2 - a clinical and ethnological trial on the role of protein supplementation and training load (CALM Intervention Study): study protocol for a randomized controlled trial

AU - Bechshøft, Rasmus

AU - Reitelseder, Søren

AU - Højfeldt, Grith

AU - Castro Mejia, Josue Leonardo

AU - Khakimov, Bekzod

AU - Bin Ahmad, Hajar Fauzan

AU - Kjær, Michael

AU - Engelsen, Søren Balling

AU - Laugesen, Susanne Margrete Bølling

AU - Rasmussen, Morten Arendt

AU - Lassen, Aske Juul

AU - Jensen, Tenna

AU - Beyer, Nina

AU - Serena, Anja

AU - Perez-Cueto, Armando

AU - Nielsen, Dennis Sandris

AU - Jespersen, Astrid Pernille

AU - Holm, Lars

PY - 2016

Y1 - 2016

N2 - BackgroundAging is associated with decreased muscle mass and functional capacity, which in turn decrease quality of life. The number of citizens over the age of 65 years in the Western world will increase by 50 % over the next four decades, and this demographic shift brings forth new challenges at both societal and individual levels. Only a few longitudinal studies have been reported, but whey protein supplementation seems to improve muscle mass and function, and its combination with heavy strength training appears even more effective. However, heavy resistance training may reduce adherence to training, thereby attenuating the overall benefits of training. We hypothesize that light load resistance training is more efficient when both adherence and physical improvement are considered longitudinally. We launched the interdisciplinary project on Counteracting Age-related Loss of Skeletal Muscle Mass (CALM) to investigate the impact of lifestyle changes on physical and functional outcomes as well as everyday practices and habits in a qualitative context.MethodsWe will randomize 205 participants older than 65 years to be given 1 year of two daily nutrient supplements with 10 g of sucrose and 20 g of either collagen protein, carbohydrates, or whey. Further, two groups will perform either heavy progressive resistance training or light load training on top of the whey supplement.DiscussionThe primary outcome of the CALM Intervention Study is the change in thigh cross-sectional area. Moreover, we will evaluate changes in physical performance, muscle fiber type and acute anabolic response to whey protein ingestion, sensory adaptation, gut microbiome, and a range of other measures, combined with questionnaires on life quality and qualitative interviews with selected subjects. The CALM Intervention Study will generate scientific evidence and recommendations to counteract age-related loss of skeletal muscle mass in elderly individuals.

AB - BackgroundAging is associated with decreased muscle mass and functional capacity, which in turn decrease quality of life. The number of citizens over the age of 65 years in the Western world will increase by 50 % over the next four decades, and this demographic shift brings forth new challenges at both societal and individual levels. Only a few longitudinal studies have been reported, but whey protein supplementation seems to improve muscle mass and function, and its combination with heavy strength training appears even more effective. However, heavy resistance training may reduce adherence to training, thereby attenuating the overall benefits of training. We hypothesize that light load resistance training is more efficient when both adherence and physical improvement are considered longitudinally. We launched the interdisciplinary project on Counteracting Age-related Loss of Skeletal Muscle Mass (CALM) to investigate the impact of lifestyle changes on physical and functional outcomes as well as everyday practices and habits in a qualitative context.MethodsWe will randomize 205 participants older than 65 years to be given 1 year of two daily nutrient supplements with 10 g of sucrose and 20 g of either collagen protein, carbohydrates, or whey. Further, two groups will perform either heavy progressive resistance training or light load training on top of the whey supplement.DiscussionThe primary outcome of the CALM Intervention Study is the change in thigh cross-sectional area. Moreover, we will evaluate changes in physical performance, muscle fiber type and acute anabolic response to whey protein ingestion, sensory adaptation, gut microbiome, and a range of other measures, combined with questionnaires on life quality and qualitative interviews with selected subjects. The CALM Intervention Study will generate scientific evidence and recommendations to counteract age-related loss of skeletal muscle mass in elderly individuals.

U2 - 10.1186/s13063-016-1512-0

DO - 10.1186/s13063-016-1512-0

M3 - Journal article

VL - 17

JO - Trials

JF - Trials

SN - 1745-6215

M1 - 397

ER -

ID: 166431162